Composites of Polyvinyl Alcohol And Chitosan Reinforced With Zinc Oxide Nanoparticles for Regenerative Therapy
DOI:
https://doi.org/10.15665/rp.v23i1.3565Palabras clave:
Chitosan composites; Polyvinyl alcohol; Tissue engineering; Zinc oxide nanoparticles.Resumen
Recientemente, ha aumentado la demanda por terapias alternativas para la restauración de tejidos basadas en biomateriales que faciliten los procesos de restauración del tejido y eviten infecciones microbianas. En este trabajo, se sintetizaron cuatro formulaciones de composites basados en alcohol polivinílico (PVA), quitosano (CS) y nanopartículas de óxido de zinc (ZnO-NPs). Las principales bandas en el espectro infrarrojo del PVA y del CS fueron evidenciadas, así como la incorporación de las NPs-ZnO. El análisis termogravimétrico (TGA) y la calorimetría de barrido diferencial (DSC) demostraron que la interacción de las ZnO-NPs con el grupo carbonilo desestabiliza térmicamente a los composites. El estudio morfológico mediante microscopía electrónica de barrido (SEM) demostró que los composites incorporados con ZnO-NPs presentan una microestructura porosa irregular y rugosa, debido a la evaporación del solvente. El examen de los composites implantados mediante análisis histológico demostró su biocompatibilidad y biodegradabilidad 60 días después de la implantación. La degradación simultánea y la formación de fibras de colágeno de tipo I, con el aumento de los vasos sanguíneos y la inflamación, indican un material altamente biocompatible y reabsorbible, lo que podría potencialmente revolucionar la terapia regenerativa
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